His brother Ernest was the Bishop of Worcester from 1919 to 1930. Pearce was ordained in 1899. His career began with a curacy at St James, Muswell Hill. He was then Vicar of St Bene't's, Cambridge, Dean then Master of his old college Corpus Christi, Cambridge from 1914 and finally (before his elevation to the episcopate) Vice-Chancellor of the University. He died while taking a confirmation service near Glossop.